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PME 7.2.2 web application HTTP Error 500.21 - Internal Server Error Handler "PageHandlerFactory-Integrated" has a bad module "ManagedPipelineHandler" in its module list

Issue
Attempting to access the PME 7.2.2 Web application in a browser yields the following error:
[Error Summary]
HTTP Error 500.21 - Internal Server Error
Handler "PageHandlerFactory-Integrated" has a bad module "ManagedPipelineHandler" in its module list

Environment
PME 7.2.2 Web Applications

Cause
.NET was not registered with IIS during the upgrade or re-install.

Resolution
Run the following command in the Windows command line or powershell as administrator to re-install .NET.
%windir%\Microsoft.NET\Framework\v4.0.30319\aspnet_regiis.exe -i

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